According to Otherside Entertainment's Warren Spector, the game will pick up where System Shock 2 left off, with SHODAN surviving by downloading her consciousness into Rebecca Siddons (the post-credits scene depicting that this happened will be considered fully canon).
A few other surviving characters from the first two games will appear, particularly Rebecca Lansing (the Earth-stationed counter-terrorism agent who guided the Hacker through e-mail transmissions in the first game), as well as the return of the two prior protagonists, the Hacker and Soldier G65434-2.
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